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| First Name: | Linda | | Last Name: | Van Eldik | | Title: | Director, Sanders-Brown Center on Aging; Vernon Smith Endowed Professor > in Alzheimer Research; Professor, Dept. Anatomy and Neurobiology | | Advanced Degrees: | Ph.D. | | Affiliation: | University of Kentucky | | Department: | Department of Anatomy and Neurobiology | | Street Address 1: | 101 Sanders-Brown Bldg. | | Street Address 2: | 800 S. Limestone St. | | City: | Lexington | | State/Province: | KY | | Zip/Postal Code: | 40507 | Country/Territory: | U.S.A. | | Phone: | 859-323-6040 | | Email Address: |  |
Disclosure:
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View all comments by Linda Van Eldik
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Neuroinflammation, drug discovery, Molecular and Cell biology, Proteomics, A-beta PP/A-beta, Neurobiology, Signal transduction
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PhD, 1977, Duke University
Postdoctoral 1978-81, Rockefeller University
Asst, Assoc, Full Professor, 1981-94, Vanderbilt University
Full Professor, 1994-present, Northwestern Univ
Associate Director of Northwestern Alzheimer's Disease Center |
Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ and Griffin WST (1996) In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiology of Aging 17:761-766.
Hu J, Akama KT, Krafft GA, Chromy BA and Van Eldik LJ (1998) Amyloid beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Research 785:195-206.
Akama KT, Albanese C, Pestell RG and Van Eldik LJ (1998) Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkB-dependent mechanism. Proc Natl Acad Sci USA 95:5795-5800.
Petrova TV, Akama KT and Van Eldik LJ (1999) Cyclopentenone prostaglandins suppress activation of microglia: downregulation of inducible nitric oxide synthase by 15-deoxy-*12,14 prostaglandin J2. Proc Natl Acad Sci USA 96:4668-4673.
Petrova TV, Akama KT and Van Eldik LJ (1999) Selective modulation of BV-2 microglial activation by prostaglandin E2: differential effects on endotoxin-stimulated cytokine induction. J Biol Chem 274:28823-28827.
Hu J and Van Eldik LJ (1999) Glial-derived proteins activate cultured astrocytes and enhance b amyloid- induced astrocyte activation. Brain Res 842:46-54.
Akama KT and Van Eldik LJ (2000) beta-Amyloid stimulation of inducible nitric oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFa)-dependent, and involves a TNFa receptor-associated factor- and NFkB-inducing kinase-dependent signaling mechanism. J Biol Chem 275: 7918-7924.
LaDu MJ, Shah JA, Reardon K, Getz GS, Bu G, Hu J, Guo L and Van Eldik LJ (2000) Apolipoprotein E receptors mediate the effects of beta-amyloid on primary astrocyte cultures. J Biol Chem 275:33974-33980.
Watterson DM, Mirzoeva S, Guo L, Whyte A, Bourguignon J-J, Hibert M, Haiech J and Van Eldik LJ (2001) Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin-1b and nitric oxide synthase II. Neurochem Intl 39: 459-468.
Mirzoeva S, Sawkar A, Zasadzki M, Guo L, Velentza A, Dunlap V, Bourguignon J-J, Ramstrom H, Haiech J, Van Eldik LJ and Watterson DM (2002) Discovery of a 6-amino-3-phenylpyridazine derivative as a new synthetic anti-neuroinflammatory compound. J Med Chem 45: 563-566.
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The quantitative contribution of each of the large number of contributing factors to AD progression.
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Selective anti-neuroinflammatory compounds that block the detrimental signal transduction responses of chronically activated glial cells will be useful to slow progression of pathology in AD. |
We are testing this hypothesis now by developing these kinds of selective compounds, and testing them in relevant cell-based and animal models. |
It's working so far. We may have to target different pathways if the particular compounds we test do not work like we anticipate. |
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